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Market Overview

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The single cell RNA sequencing market is projected to reach a value of $2,931 million by 2031, growing at a compound annual growth rate (CAGR) of 17.08% during the forecast period from 2021 to 2031. This technology allows for the sequencing of individual cells, providing insights into genomics, transcriptomics, and multi-omics of single cells. It has revolutionized transcriptomic studies and offers significant potential for new discoveries.

Single cell RNA sequencing enables the comprehensive analysis of individual cells and has opened doors for understanding cell heterogeneity and gene expression. The availability of next-generation sequencing and advancements in bioinformatics have contributed to its commercial adoption. This technology has found applications in embryonic development, cancer biology, immunology research, and other fields.

Studying cell-to-cell variation is crucial for drug discovery, diagnostics, and prognostics. Next-generation sequencing technologies are increasingly focusing on characterizing individual cells to reveal unexpected discoveries that may differ from bulk population assessments.

The development of single cell RNA sequencing can be traced back to 2009 when it was initially performed on four-cell stage blastomeres in mice. Later, multiplexed single cell RNA sequencing was developed, followed by the availability of commercial single cell platforms in 2014. Since then, the market for single cell RNA sequencing has been expanding rapidly and is expected to grow exponentially in the future. Its capability of providing detailed transcriptomic information makes it highly valuable for advanced research and accurate diagnostics.

Several factors are driving the market growth, including the increasing application of single cell RNA sequencing in cancer studies and treatment, growing awareness and acceptance of personalized diagnostics globally, decreasing sequencing costs, and rising government funding for healthcare.

However, there are challenges to overcome, such as computational difficulties in analyzing large amounts of data generated by single cell RNA sequencing, high capital requirements for implementing the technology, and the lack of infrastructure and expertise in some regions.

Nevertheless, there are opportunities for market expansion, including entering emerging markets, exploring new research applications, and expanding the product portfolio to cater to diverse needs.

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Market Segmentation

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The market is segmented based on various factors, including workflow type, offering type, application, end user, and region.

Segmentation by Workflow Type
Single Cell Isolation
Single Cell Amplification
Library Preparation

Segmentation by Offering Type
Consumables
Instruments

Segmentation by Application Type
Oncology
Neurology
Immunology
Embryology
Others

Segmentation by End-User Type
Research Organizations
Biopharmaceutical Companies
Others

Segmentation by Region
North America – U.S., Canada
Europe – Germany, France, Italy, U.K., Spain, and Rest-of-Europe
Asia-Pacific – China, Japan, Australia, India, South-Korea and Rest-of-Asia-Pacific (RoAPAC)
Rest-of-the-World

The global single cell RNA sequencing market encompasses several steps in its workflow. Notably, single cell isolation and single cell amplification are critical steps prior to sequencing. Key companies employ various technologies for these steps. Currently, library preparation dominates the global single cell RNA sequencing market in terms of workflow type. In 2020, the contribution of library preparation was valued at $199 million, and it is expected to reach $1,564 million by 2031, with a projected compound annual growth rate (CAGR) of 17.48% during the forecast period from 2021 to 2031. Library preparation has made significant advancements in recent years, offering more accurate and faster results with lower input of RNA and DNA, making it the preferred choice over other technologies. During RNA library preparation, the RNA transcript is converted into complementary DNA (cDNA), and strand-specific RNA library preparation enhances RNA sequencing by accurately identifying antisense transcripts, non-coding RNA, and distinguishing gene boundaries in close proximity or overlapping regions.

In terms of offerings, consumables currently dominate the global single cell RNA sequencing market. The contribution of consumables was valued at $309 million in 2020, and it is expected to reach $2,454 million by 2031, with a projected CAGR of 17.32% during the forecast period from 2021 to 2031. The consumables market for single cell RNA sequencing consists of kits and panels for library preparation, target enrichment, and sequencing. Since single cell analysis requires specific application-specific kits, the cost of these kits is higher compared to those available for next-generation sequencing (NGS). Therefore, key manufacturers are striving to streamline and simplify the single cell analysis workflow by providing ready-to-use kits and panels capable of conducting a greater number of reactions at a reduced cost.

In terms of application type, oncology currently dominates the global single cell RNA sequencing market. In 2021, the contribution of oncology was valued at $95.1 million, and it is expected to reach $790 million by 2031, with a projected CAGR of 18.05% during the forecast period from 2021 to 2031. Single cell RNA sequencing has revolutionized the field of cancer genomics, enabling researchers to gain a better understanding of cancer diagnosis, monitoring, and treatment. Through the identification of genomic, epigenomic, and transcriptomic changes in cancer, personalized treatments, biomarker discovery, accurate classification, and improved understanding of the mechanical properties of cancer have become possible.

Research organizations currently dominate the global single cell RNA sequencing market in terms of end users. In 2020, the contribution of research organizations was valued at $278 million, and it is expected to reach $2,028 million by 2031, with a projected CAGR of 16.91% during the forecast period from 2021 to 2031. Research organizations play a vital role in validating and identifying the diverse applications of single cell RNA sequencing since the technology is still in its early stages with limited discovered applications. These organizations serve as essential facilities for companies and independent academic research, utilizing next-generation sequencing primarily for research purposes such as biomarker identification, drug development, and acquiring targets from single cell analysis. Additionally, research organizations contribute to exploring new opportunities for advancing molecular diagnostic technologies and capabilities.

In 2020, North America was one of the most attractive markets globally for single cell RNA sequencing. However, Europe is expected to gain more market shares in the coming years due to the presence of numerous biotechnology-based firms in the region and the higher demand for single cell RNA sequencing in European countries. Furthermore, India is projected to be the fastest-growing nation globally in this market, driven by increasing affordability and awareness in the region.

The North America single cell RNA sequencing market was valued at $198 million in 2020 and is expected to reach $1,469 million by 2031, growing at a CAGR of 16.83% during the forecast period from 2021 to 2031. The expansion of this market is primarily supported by the development of analysis platforms for gene and protein expression, as well as advancements in innovative single cell genomics initiatives. Moreover, the discovery of advanced biomarker tests specific to diseases has led to the development of targeted therapies and drug discoveries, thereby increasing the acceptance of single cell technology among researchers and physicians. These factors collectively contribute to the growth of the single cell RNA sequencing market in North America.

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Competitive Landscape

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The competitive landscape offers an organization a valuable perspective to comprehend its primary business strategy within the industry, assess its existing competitors, and identify potential future competitors that may have entered the market. This section provides comprehensive insights into the recent strategies and advancements undertaken by prominent market players in the global single cell RNA sequencing market. To establish market leadership and actively participate in market expansion, companies must introduce novel products, invest in innovations, and engage in collaborations with leading top-tier component providers to enhance their market position.

Key companies profiled in this report include 10x Genomics, Inc., BGI Group, Bio-Rad Laboratories, Inc., Becton, Dickinson and Company (BD), Fluidigm Corporation, MedGenome, NanoString Technologies, Inc., Pacific Biosciences of California, Inc., QIAGEN N.V., PerkinElmer Inc., Takara Bio, Inc., Thermo Fisher Scientific Inc.

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Key Questions Answered

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What are the primary applications of single cell RNA sequencing technology?

What are the alternative technologies that compete with single cell RNA sequencing technology?

What are the major drivers, challenges, and opportunities in the global market for single cell RNA sequencing?

What are the key strategies implemented by major players to establish their presence in this market?

Which companies are the leading players dominating the global market for single cell RNA sequencing?

What is the market share of these companies in the global single cell RNA sequencing market?

What are the regulations governing the global market for single cell RNA sequencing?

What initiatives have different government bodies implemented to regulate the development and commercialization of single cell RNA sequencing?

How is each segment of the global single cell RNA sequencing market expected to grow and generate revenue by the end of 2031?

How will the global single cell RNA sequencing industry evolve during the forecast period of 2021-2031?

What is the market scenario for the global single cell RNA sequencing market in different regions?

What are the key trends observed in different regions of the single cell RNA sequencing market?

Which country is expected to contribute the most to the sales of the single cell RNA sequencing market during the forecast period of 2021-2031?

What has been the impact of COVID-19 on the single cell RNA sequencing market?