市場概況

The global market for Alzheimer’s disease therapeutics had a value of USD 3.59 億で 2022 そして米ドルに達すると予測されています 7.16 10億まで 2028, 年間複利成長率 (CAGR) の 12.19% からの期間中 2022 に 2028. This growth can be attributed to the increasing prevalence of Alzheimer’s disease worldwide, leading to heavy investments in therapeutic development by both government and non-government entities. Research and development (R&D) investments are expected to further drive the growth of the Alzheimer’s disease therapeutics market.

China had the highest prevalence of Alzheimer’s disease in 2021, followed by the United States and Japan. The total number of cases in the eight major markets (8MM) is expected to increase from 29,460,996 で 2021 に 36,009,144 cases in 2028. The rising prevalence of Alzheimer’s disease is a key driver of the global market for Alzheimer’s disease therapeutics. In the United States alone, 約 900,000 new patients are diagnosed annually.

The most significant known risk factor for Alzheimer’s disease is advancing age, with the majority of affected individuals being 65 years and older. If the disease affects a person under 65, it is considered younger-onset or early-onset Alzheimer’s. Alzheimer’s disease is the most common form of dementia and affected approximately 5.8 million people in the United States in 2020, with the prevalence expected to double by 2050. 世界的に, 推定 35 million people are affected by Alzheimer’s disease. ヨーロッパで, as of 2018, 9.7 million people have Alzheimer’s disease or other forms of dementia, a number projected to rise to 14 百万までに 2030. Japan has the highest total prevalence of Alzheimer’s disease, と 23.88% in women and 11.93% in men. The total number of prevalent cases in individuals aged 60 years and older is expected to increase from 4.2 百万で 2022 に 5.1 百万で 2028, representing an annual growth rate of 3.5%. The growing number of Alzheimer’s disease cases presents significant growth opportunities for the Alzheimer’s disease therapeutics market.

Various laboratory tests can diagnose Alzheimer’s disease, including assessments of memory impairment, thinking skills, functional abilities, and behavior changes. Commonly used brain-imaging technologies include Magnetic Resonance Imaging (MRI), Computerized Tomography (CT), and Positron Emission Tomography (ペット).

現在, the competitive landscape of Alzheimer’s disease therapeutics primarily consists of symptomatic treatments. There are seven approved medications, including three Cholinesterase inhibitors (donepezil, rivastigmine, and galantamine), one NMDA-R antagonist (memantine), one combination therapy (memantine/donepezil), and two Aβ A4 protein inhibitors (aducanumab and sodium oligomannate). Cholinesterase inhibitors are the main drugs available for Alzheimer’s disease due to the significant therapeutic target they address. Improvements to the approved therapies, such as easier administration routes and reduced dosing frequencies, along with anticipated developments in the next decade, can have a significant impact on disease management. Early detection could enhance the usefulness of currently available therapies, but until disease-modifying agents are introduced, the treatment landscape is unlikely to change significantly.

The Alzheimer’s disease therapeutics market currently comprises over 151 assets in various development phases. Most industry-sponsored drugs in active clinical development for Alzheimer’s disease are in Phase II.

The clinical trial portfolio includes over 139 trials in different development phases, with the majority of industry-sponsored drugs in active clinical development for Alzheimer’s disease being in Phase II. The global pharmaceutical industry is steadily developing new drugs for Alzheimer’s disease, a central nervous system disorder. North America leads in terms of ongoing clinical trials involving Alzheimer’s disease, followed by Asia-Pacific and Europe. Eli Lilly and Company is the leading sponsor of ongoing Alzheimer’s disease-related clinical trials in the Alzheimer’s disease therapeutics market, with other notable sponsors including Eisai Co Ltd, Roche Ltd, Cognition Therapeutics Inc, and Cassava Sciences Inc.

の 2021, the US Food and Drug Administration (USFDA) approved the biologic drug candidate Aducanumab (Aduhelm) for the treatment of early Alzheimer’s disease. With Aduhelm becoming the first approved biologic therapy for Alzheimer’s disease in 2021, there is a growing demand for biologic therapies with novel mechanisms of action. Many new classes of therapies are expected to enter the Alzheimer’s disease therapeutics market in the coming years. Biologics such as amyloid beta inhibitors are gaining traction in the Alzheimer’s disease market due to their improved clinical profiles and convenient patient dosing. The launch of approved small molecules and the increased adoption of biologic therapies will contribute to significant growth in the Alzheimer’s disease therapeutics market.

The Alzheimer’s disease therapeutics market has been experiencing significant growth due to the rising prevalence of Alzheimer’s disease worldwide. の 2022, it was estimated that there were 6.5 million Alzheimer’s disease patients in the United States.

Major players in the Alzheimer’s disease therapeutics market are actively developing novel products and investing heavily in research and development. They are also engaged in major acquisitions and collaborations to gain a competitive advantage. High investments in R&D capabilities and infrastructure by both the industry and governments are expected to create lucrative opportunities in the market.

市場セグメンテーション

市場はさまざまな要因に基づいて分割されます, including drug class, gender type, 年齢層, severity type, そして地理.

Segmentation By Drug Class
ACE Inhibitors
NMDA Inhibitors
Other Drug class

Segmentation By Gender Type
男性
女性

Segmentation By Age Group
65-74 年
75-84 年
85 年 & その上

Segmentation By Severity Type
軽度
適度
Severe

地理によるセグメンテーション
北米 – 私たち
ヨーロッパ – ドイツ, フランス, イギリス, イタリア, スペイン
アジア太平洋 – 中国, 日本

Drug Class: ACE inhibitors are projected to hold a significant share in the global Alzheimer’s disease therapeutics market by drug class. しかし, the fastest-growing segment during the forecast period is expected to be the other class of drugs. The recent approval of biologics like Aducanumab (Aduhelm) is anticipated to drive the global Alzheimer’s disease therapeutics market in the coming years.

Gender Type: Women are expected to contribute significantly to the global Alzheimer’s disease therapeutics market in terms of gender type. This dominance can be attributed to women’s longer life expectancy, which results in a larger population affected by Alzheimer’s disease.

Age Group: Among different age groups, の 85 years and above demographic is expected to dominate the global Alzheimer’s disease therapeutics market. しかし, the fastest-growing segment during the study period is projected to be the population aged 65 years and above.

Severity Type: Individuals with mild forms of Alzheimer’s disease are expected to hold a significant share in the global therapeutics market. の 2021, the incidence of Alzheimer’s disease in the U.S. was reported to be 229,385, and this number is predicted to increase substantially during the forecast period. 一方で, the fastest-growing segment is expected to be individuals with moderate forms of the disease.

地理的に, the United States holds a dominant position in the global Alzheimer’s disease therapeutics market. This is attributed to factors such as increased affordability of healthcare, growing knowledge and awareness among the population, and technological advancements in the region. しかし, it is expected that China will experience faster growth with a high compound annual growth rate (CAGR) in the global Alzheimer’s disease therapeutics market. This can be attributed to the rising geriatric population, increased awareness about disease management, and growing healthcare expenditure in the Asia-Pacific (アジア太平洋) 地域.

競争環境

The current competitive landscape in Alzheimer’s Disease (AD) primarily consists of symptomatic treatments, with a total of seven approved medications currently available. The global market for Alzheimer’s disease therapeutics is predominantly led by various companies offering generic drugs, as well as selective pharmaceutical and biotechnology companies providing patented or commercially developed drugs for the treatment of Alzheimer’s Disease. の 2021, アメリカ. 食品医薬品局 (FDA) granted approval for the amyloid beta antibody Aduhelm (Aducanumab), marking the introduction of biologic therapies in this treatment arena. While generic products continue to hold a significant share of the Alzheimer’s disease therapeutics market, the emergence of biologics and other targeted therapies signifies a notable shift in the therapeutic landscape throughout the projected period.

The global Alzheimer’s disease therapeutics market comprises over 151 assets in various stages of development. Emerging therapeutics being developed for Alzheimer’s Disease include Lecanemab, Nilotinib, Remternetug, NE-3107, Bepranemab, Vafidemstat, Seltorexant, 他にもいくつか. The introduction of these novel emerging drugs is expected to revolutionize the paradigm of Alzheimer’s Disease therapeutics in the near future. With more than 151 molecules at different stages of development, it is anticipated that new market entrants will bring forth innovative mechanisms of action and improved safety and efficacy profiles compared to the existing patented commercial drugs for treating Alzheimer’s Disease.

Prominent players in the global Alzheimer’s disease therapeutics market include Eisai Co., 株式会社, ノバルティス, Biogen, アッヴィ, ヤンセンファーマ株式会社, and Shanghai Green Valley Pharmaceuticals. These companies pursue both organic and inorganic growth strategies to enhance their product portfolios. Strategies such as collaborations, 買収, geographical expansion, research and development investments, and the development of novel drugs are employed by these companies to compete in the global Alzheimer’s disease therapeutics market. Other emerging players of significance in the global Alzheimer’s disease market include KeifeRx LLC, BioVie Inc, イーライリリー アンド カンパニー, UCB SA, Oryzon Genomics, Denali Therapeutics, and various others.

Key companies profiled in this report include Novartis AG, AbbVie Inc (アッヴィ), Biogen Inc (Biogen), ジョンソン & ジョンソン (J&J), Eisai Co Ltd (Eisai), Green Valley Pharmaceuticals, UCB SA (UCB), KeifeRx, Eli Lilly and Co (Lilly), BioVie Inc, NeuroKine Therapeutics (NKT), LLC, Vaccinex, 株式会社, Alzinova AB, Asceneuron SA, Biohaven, Denali, Alzamend.

最近の業界の発展

4月中 2022, Biogen made an announcement stating that the European Medicines Agency (EMA) had withdrawn the Marketing Authorization Application (MAA) for aducanumab, a treatment for early-stage Alzheimer’s disease. This decision was based on the insufficiency of data provided.

3月 2022, Corium, 株式会社. announced that the U.S. 食品医薬品局 (FDA) had granted approval for Adlarity (donepezil transdermal system) as a treatment for patients with mild, 適度, or severe dementia caused by Alzheimer’s Disease.

六月に 2021, Biogen revealed that the U.S. 食品医薬品局 (FDA) had granted accelerated approval for Aduhelm (aducanumab-avwa) to treat early-stage Alzheimer’s disease. This approval was based on the results of two Phase 3 clinical trials—EMERGE (Study 1) and ENGAGE (Study 2)—conducted on patients in the early stages of Alzheimer’s disease, specifically those with mild cognitive impairment and mild dementia, who exhibited confirmed amyloid pathology.

主な質問への回答

What is the projected market size of the Alzheimer’s disease therapeutics market?

The projected market size for the Alzheimer’s disease therapeutics market is expected to reach USD 7.16 10億まで 2028.

年間複利成長率とは (CAGR) of the global Alzheimer’s disease therapeutics market?

The global Alzheimer’s disease therapeutics market is experiencing a compound annual growth rate (CAGR) の 12.19% から 2022 に 2028.

What are some notable trends observed in the Alzheimer’s disease therapeutics market?

Prominent trends in the Alzheimer’s disease therapeutics market include substantial investments in research and development (R&D) and the presence of key industry players.

Who are the leading vendors operating in the global Alzheimer’s disease therapeutics market?

ノバルティスAG, アッヴィ, Biogen, ジョンソン & ジョンソン (J&J), Eisai, Green Valley Pharmaceuticals, UCB SA (UCB), KeifeRx, Eli Lilly And Co, BioVie Inc, and NeuroKine Therapeutics are among the leading vendors operating in the global Alzheimer’s disease therapeutics market.

Which region dominates the global Alzheimer’s disease therapeutics market in terms of market share?

現在 2022, the United States holds the largest market share in the global Alzheimer’s disease therapeutics market.